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Is one vaccine dose enough if you’ve had COVID? What the science says

Research shows that a previous coronavirus infection plus one dose of vaccine provides powerful protection — but concerns linger.
  1. Elie Dolgin

    1. Elie Dolgin is a science journalist in Somerville, Massachusetts.

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Many people who’ve been infected with the coronavirus might be able to safely skip the second jab of any two-dose vaccine regimen, a growing number of studies suggest. These results could help to stretch scarce vaccine supplies and are already influencing vaccination policies in some countries. But questions remain about whether the findings hold for all individuals and all vaccines — and therefore how policymakers should respond to the findings.

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Nature 595, 161-162 (2021)

doi: https://doi.org/10.1038/d41586-021-01609-4

References

  1. Stamatatos, L. et al. Science 372, 1413–1418 (2021).

    Article  Google Scholar 

  2. Goel, R. R. et al. Sci. Immunol. 6, eabi6950 (2021).

    Article  PubMed  Google Scholar 

  3. Ebinger, J. E. et al. Nature Med. 27, 981–984 (2021).

    Article  Google Scholar 

  4. Krammer, F. et al. N. Engl. J. Med. 384, 1372–1374 (2021).

    Article  PubMed  Google Scholar 

  5. Wang, Z. et al. Nature https://doi.org/10.1038/s41586-021-03696-9 (2021).

    Article  Google Scholar 

  6. Camara, C., et al. Preprint at bioRxiv https://doi.org/10.1101/2021.03.22.436441 (2021).

  7. Mazzoni, A. et al. J. Clin. Invest. https://doi.org/10.1172/JCI149150 (2021).

    PubMed  Google Scholar 

  8. Nadesalingam, A. et al. Preprint at medRxiv https://doi.org/10.1101/2021.06.03.21257901 (2021).

  9. Sasikala, M. et al. Int. J. Infect. Dis. 108, 183–186 (2021).

    Article  PubMed  Google Scholar 

  10. Frieman, M. et al. eBioMedicine 68, 103401 (2021).

    Article  PubMed  Google Scholar 

Download references

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