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  • OUTLOOK

Is there more to a healthy-heart diet than cholesterol?

A high-fat diet is thought to increase the risk of a heart attack. But some say that the long-held dogma of ‘bad’ cholesterol might be flawed.
  1. Natalie Healey

    1. Natalie Healey is a journalist in London.

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Shortly after the end of the Second World War, large numbers of wealthy businessmen in the United States began dying from heart attacks. Shocked by the obituaries mounting up in his local newspaper, physiologist Ancel Keys decided to investigate. His findings would fundamentally change the way we eat for decades to come.

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Nature 594, S12-S13 (2021)

doi: https://doi.org/10.1038/d41586-021-01455-4

This article is part of Nature Outlook: Heart health, an editorially independent supplement produced with the financial support of third parties. About this content.

References

  1. Keys, A. (ed.) Circulation 41, S1–S211 (1970).

    Google Scholar 

  2. Kannel, W. B., Dawber, T. R., Kagan, A. & Stokes, J. Ann. Intern. Med. 55, 33–50 (1961).

    Article  PubMed  Google Scholar 

  3. The Lipid Research Clinics Coronary Primary Prevention Trial. J. Am. Med. Assoc. 251, 351–364 (1984).

    Article  Google Scholar 

  4. Scandinavian Simvastatin Survival Study Group. Lancet 344, 1383–1389 (1994).

    PubMed  Google Scholar 

  5. Collins, R. et al. Lancet 388, 2532–2561 (2016).

    Article  PubMed  Google Scholar 

  6. DuBroff, R., Malhotra, A. & de Lorgeril, M. BMJ Evid. Based Med. https://doi.org/ghzn8g (2020).

    Article  Google Scholar 

  7. Kearns, C. E., Schmidt, L. A. & Glantz, S. A. JAMA Intern. Med. 176, 1680–1685 (2016).

    Article  PubMed  Google Scholar 

  8. Dehghan, M. et al. Lancet 390, 2050–2062 (2017).

    Article  PubMed  Google Scholar 

  9. Ravnskov, U. et al. BMJ Open 6, e010401 (2016).

    Article  PubMed  Google Scholar 

  10. Hua, J. & Malinski, T. Int. J. Nanomed. 14, 8973–8987 (2019).

    Article  Google Scholar 

Download references

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