Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • RESEARCH SUMMARY

Mining the gaps of chromosome 8

The first gapless, telomere-to-telomere sequence of a human autosome, chromosome 8, is complete. Sequencing and assembly of the corresponding centromere in the chimpanzee, orangutan and macaque reveals details of its rapid evolution over the past 25 million years.
  1. Glennis A. Logsdon

    1. Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA.

    View author publications

    You can also search for this author in PubMed  Google Scholar

  2. Evan E. Eichler

    1. Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA, and Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.

    View author publications

    You can also search for this author in PubMed  Google Scholar

This is a summary of Logsdon, G. A. et al. The structure, function and evolution of a complete human chromosome 8. Nature https://doi.org/10.1038/s41586-021-03420-7 (2021).

Access options

Prices may be subject to local taxes which are calculated during checkout

doi: https://doi.org/10.1038/d41586-021-01095-8

References

  1. Logsdon, G. A., Vollger, M. R. & Eichler, E. E. Nature. Rev. Genet. 21, 597–614 (2020).

    Article  PubMed  Google Scholar 

  2. Chaisson, M. J. P. et al. Nature 517, 608–611 (2015).

    Article  PubMed  Google Scholar 

  3. Jain, M. et al. Nature Biotechnol. 36, 338–345 (2018).

    Article  PubMed  Google Scholar 

  4. Ebert, P. et al. Science 372, eabf7117 (2021).

    Article  PubMed  Google Scholar 

  5. Vollger, M. R. et al. Ann. Hum. Genet. 84, 125–140 (2020).

    Article  PubMed  Google Scholar 

  6. Nurk, S. et al. Genome Res. https://doi.org/10.1101/gr.263566.120 (2020).

    Article  Google Scholar 

  7. Cheng, H., Concepcion, G. T., Feng, X., Zhang, H. & Li, H. Nature Methods 18, 170–175 (2021).

    Article  PubMed  Google Scholar 

  8. Bzikadze, A. V. & Pevzner, P. A. Nature Biotechnol. 38, 1309–1316 (2020).

    Article  PubMed  Google Scholar 

  9. Miga, K. H. et al. Nature 585, 79–84 (2020).

    Article  PubMed  Google Scholar 

Download references

Competing Interests

The authors declare no competing interests.

Subjects

Latest on:

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Advanced search

Quick links