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Mutation alters chromatin changes during injury response to drive cancer

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Nature 590, 557-558 (2021)


Updates & Corrections

  • Correction 08 February 2021: This article incorrectly described KRAS as a type of enzyme termed a kinase. It is a GTPase.


  1. Giroux, V. & Rustgi, A. K. Nature Rev. Cancer 17, 594–604 (2017).

    Article  PubMed  Google Scholar 

  2. Alonso-Curbelo, D. et al. Nature 590, 642–648 (2021).

    Article  Google Scholar 

  3. Guerra, C. et al. Cancer Cell 11, 291–302 (2007).

    Article  PubMed  Google Scholar 

  4. Habbe, N. et al. Proc. Natl Acad. Sci. USA 105, 18913–18918 (2008).

    Article  PubMed  Google Scholar 

  5. Storz, P. Nature Rev. Gastroenterol. Hepatol. 14, 296–304, (2017).

    Article  PubMed  Google Scholar 

  6. Li, Y. et al. Nature Cancer 2, 49–65 (2021).

    Article  Google Scholar 

  7. Whyte, W. A. et al. Cell 153, 307–319 (2013).

    Article  PubMed  Google Scholar 

  8. Mazur, P. K. et al. Nature Med. 21, 1163–1171 (2015).

    Article  PubMed  Google Scholar 

  9. Gilan, O. et al. Science 368, 387–394 (2020).

    Article  PubMed  Google Scholar 

  10. Beyer, G., Habtezion, A., Werner, J., Lerch, M. M. & Mayerle, J. Lancet 396, 499–512 (2020).

    Article  PubMed  Google Scholar 

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Competing Interests

M.A.D. has been a member of advisory boards for GlaxoSmithKline, CTx CRC, Storm Therapeutics, Celgene and Cambridge Epigenetix. The Dawson lab receives research funding from CTx CRC.


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