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Search for better COVID vaccines confounded by existing rollouts

As placebo-controlled testing falls out of favour, vaccine developers eye blood markers and challenge trials to assess next-generation candidates.
  1. Elie Dolgin
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Global health researchers breathed a collective sigh of relief last month after nations across Europe, North America and elsewhere issued emergency approvals of the first COVID-19 vaccines. But as the shots are rolled out, clinicians are scrambling to work out how to evaluate dozens of other, earlier-stage vaccine candidates. These could be less expensive, have fewer side effects or be easier to administer than those now in use — and they would bolster the world’s supply of COVID-19 immunizations, ensuring more rapid distribution to all countries.

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Nature 589, 340-341 (2021)

doi: https://doi.org/10.1038/d41586-021-00015-0

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