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  • RESEARCH HIGHLIGHT

How to make a 3D map of a genome — as it looks inside the cell

DNA barcodes help to detail the genomic architecture and sequence of an unbroken cell or even an entire embryo.
Eight-cell mouse embryo, light micrograph.

Genomic techniques can be used to specify the DNA sequence of cells in an entire mouse embryo (pictured). Credit: Meng Zhu, Zernicka-Goetz Laboratory, Cambridge University/SPL

A powerful method that combines microscopy and genomic analysis can reveal the organization and sequence of DNA inside intact cells.

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Nature 589, 173 (2021)

doi: https://doi.org/10.1038/d41586-021-00008-z

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