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Hit movie reveals how a tuberculosis drug halts ATP synthesis

Structural data revealing how an anti-tuberculosis drug works could aid efforts to improve therapeutic options for the disease. The findings also uncover aspects of how the drug’s target, the ATP synthase enzyme, operates.
  1. Valerie Mizrahi

    1. Valerie Mizrahi is in the Molecular Mycobacteriology Research Unit and Wellcome Centre for Infectious Diseases Research in Africa, Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa.

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  2. Clifton E. Barry III

    1. Clifton E. Barry III is in the Tuberculosis Research Section, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.

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The 2017 Nobel Prize in Chemistry was awarded for the development of an imaging method called cryo-electron microscopy. On bestowing the prize, the Royal Swedish Academy of Sciences stated that this technique has “moved biochemistry into a new era”. Writing in Nature, Guo et al.1 provide a compelling glimpse into this new age.

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Nature 589, 21-22 (2021)

doi: https://doi.org/10.1038/d41586-020-03406-x

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