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Reversal of biological clock restores vision in old mice

‘Reprogramming’ approach seems to make old cells young again.
  1. Heidi Ledford
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Researchers have restored vision in old mice and in mice with damaged retinal nerves by resetting some of the thousands of chemical marks that accumulate on DNA as cells age. The work, published on 2 December in Nature1, suggests a new approach to reversing age-related decline, by reprogramming some cells to a ‘younger’ state in which they are better able to repair or replace damaged tissue.

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Nature 588, 209 (2020)

doi: https://doi.org/10.1038/d41586-020-03403-0

Read the related News & Views, ‘Sight restored by turning back the epigenetic clock’.

References

  1. Lu, Y. et al. Nature 588, 124–129 (2020).

    Article  Google Scholar 

  2. Ocampo, A. et al. Cell 167, 1719–1733 (2016).

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