Making it in the megacity

China’s Greater Bay Area is increasingly the career destination of choice for ambitious young researchers.

Brightly lit towers crowd together in Hong Kong.

Downtown Hong Kong at night. Credit: Ratnakorn Piyasirisorost/Getty Images.

Downtown Hong Kong at night. Credit: Ratnakorn Piyasirisorost/Getty Images.

Two decades ago, many Chinese science and engineering students aspired to work overseas or to study at the country’s leading academic institutions in Shanghai and Beijing. Now, their choices have expanded to include some of the world’s most innovative and influential technology companies, such as big-data and technology firm Tencent, world-leading drone manufacturer DJI and telecommunications firm Huawei. All are home-grown Chinese companies rooted in science, and all three are based in Shenzhen, a city of more than 13 million people that, five decades ago, was little more than a collection of marshy, agricultural villages across the border from the then-UK colony of Hong Kong

Shenzhen and the ten cities surrounding it — an area known historically as the Pearl River Delta — are fast becoming a draw for scientists as China’s government knits them into an integrated economic region in a scheme known as the Guangdong–Hong Kong–Macau Greater Bay Area, or the GBA. The region is already the largest urban area in the world, with a population of 72 million people and the economic and scientific clout to match. Government plans are often lacking in detail, but the core goal is clear: to connect the individual, now-competing, cities through transport and economic links into a single megacity — in the next 15 years.

Sources: Greater Bay Area official website, Google Maps.

Sources: Greater Bay Area official website, Google Maps.

The megacity, mapped

The Greater Bay Area (GBA) is a vast region that China's federal government hopes to bring together into a single contiguous megacity.

The region hosts 11 individual conurbations, including the separately-governed regions of Hong Kong and Macau.

These districts stretch around the Pearl River delta, and more than 72 million people live in the region: making the GBA one of the world's largest urban areas.

The region has financial clout to match, with a collective GDP that tops US$1.7 trillion, rivalling that of Canada or Italy.

The GBA project involves the construction of a more expansive transport system to better knit the individual cities together.

This includes the vast Hong Kong-Macau-Zhuhai bridge (highlighted), which stretches over 50 kilometres across the Pearl River delta.

The region is also a centre of science: some of China's top-ranked universities are in the GBA.

And it is the home of several science parks that host technology companies, including Huawei and Tencent, both in Shenzhen.

Several future high-tech development hubs are planned, and a new research facility is under construction — the Jiangmen Underground Neutrino Observatory (highlighted), due to open by 2023.

Nature spoke to five early-career researchers, most of them newcomers to the GBA, who are developing their careers there.

The drug developer

Andy Tsun

Andy Tsun, wearing a white ‘Biotheus’-branded lab coat, uses a pipette.

I came to Zhuhai in 2019 to set up a drug-development firm, but I’ve always had connections with the GBA: my parents are originally from Hong Kong, but they met in the United Kingdom after their families both moved there. I grew up in Hertfordshire, just north of London. Growing up I spoke English, Hakka Chinese and Cantonese Chinese — the language that’s in everyday use in southeastern China — and I learnt Mandarin, which is the country’s dominant language, when I moved here. Having these languages has helped me in my career since.

After finishing my PhD at the University of Oxford, UK, in 2009, I moved to China to do a postdoc at the Pasteur Institute of Shanghai. Then, in 2013, I joined a biotechnology company called Innovent Biologics in Suzhou, a city about 30 minutes away from Shanghai by high-speed rail, where I was part of the team that discovered and developed a new immunotherapy for cancer. This drug, sintilimab (known as TYVYT), is now on the market in China.

In 2018, I and four friends and ex-colleagues founded Biotheus, an immuno-oncology biotech company. It focuses on discovering and developing drugs that work with the body’s immune system to fight cancer cells. By 2021 we hope to have at least five drugs in the early stages of clinical testing.

The officials in Zhuhai were very quick to persuade us to move there.

Before deciding where to locate our business, we talked to different regional governments in the GBA to see how they could support us. The regional governments all want to stimulate economic growth for their area and work hard to come up with attractive propositions for new businesses. The officials in Zhuhai were very quick to persuade us to move there. They agreed to give us a multi-million-dollar grant over three years if we moved into the Zhuhai High-tech Industrial Development Zone, a cluster of research and development start-ups, as long as we meet certain development targets, such as getting drugs to the clinical-trial stage in an allotted time frame.

Hiring isn’t particularly easy, because many scientists want to live in the larger, more established cities of Guangzhou and Shenzhen, and the local talent pool in Zhuhai is fairly small. The city is set to become a commuter suburb of Guangzhou, the capital of the province of Guangdong. The government is building a subway line that will link the two. There’s also a bridge being built that will connect Zhongshan, Zhuhai and Shenzhen to cut travel time to Shenzhen to under an hour.

Sources: Greater Bay Area project website; International Monetary Fund.

Sources: Greater Bay Area project website; International Monetary Fund.

Global scale

The Greater Bay Area's economic potential ranks among that of the world's richest countries.

You can see how the city changes day by day. There are more coffee shops, schools and cinemas. And although Zhuhai is still a rather underdeveloped area for the biotech sector, there are promising signs. One is DigiFluidic, a company launched in 2018 that is working on microfluidic technologies that will make it easier to detect disease in humans and animals. For now, we still tend to work with headhunters to attract candidates from outside Zhuhai.

We also opened a laboratory at the Hong Kong Science and Technology Park (HKSTP) in January this year, because we were able to hire a senior scientist, Suki Man-Yan Lee, who is ideally suited to lead research into the selection and screening of potential drug candidates. When we visited the HKSTP, we found that if we opened a lab there, they would agree to subsidize the salaries of staff, which would make our hiring costs lower: salaries are a lot higher in Hong Kong than in Zhuhai. We have four staff members working with Suki in Hong Kong.

Andy Tsun is a biologist and co-founder of Biotheus in Zhuhai.

Much of the Pearl River Delta, photographed by satellite in 1988. Credit: Joshua Stevens/NASA Earth Observatory, Landsat data from the U.S. Geological Survey .

Much of the Pearl River Delta, photographed by satellite in 2014. Credit: Joshua Stevens/NASA Earth Observatory, Landsat data from the U.S. Geological Survey.

Much of the Pearl River Delta, photographed by satellite in 1988. Credit: Joshua Stevens/NASA Earth Observatory, Landsat data from the U.S. Geological Survey.

Much of the Pearl River Delta, photographed by satellite in 2014. Credit: Joshua Stevens/NASA Earth Observatory, Landsat data from the U.S. Geological Survey.

Satellite imagery shows how the region has changed.

This image was taken in 1988.

And this one was taken in 2014.

The roboticist

Yun Yee Leung

Yun Yee Leung in front of a robot rig, smiling at the camera. In the background are shelves, a busy whiteboard and a computer.

Credit: Veronica Sanchis for Nature.

Credit: Veronica Sanchis for Nature.

I’m studying for my PhD in engineering at the Chinese University of Hong Kong (CUHK). Specifically, I’m training an algorithm using deep-learning techniques to guide a robotic arm to paint a piece of traditional Chinese artwork. In the future, the idea is that this research could be applied in situations where robots need to handle fragile and delicate materials, such as removing tissue to perform a biopsy or removing tumours during surgery.

There are many different work options for me after I finish my PhD. I could start a company, license my research to a manufacturer or become a consultant to businesses who need expertise in robotics.

Intelligent robots are important for the future of manufacturing, and so in my field there are plenty of well-paid engineering jobs, but also lots of people who want them.

I’m thinking about starting my own company that develops educational materials for students aged 12 to 15 years, to help them understand basic engineering ideas. These might include the logic behind designs we use every day, for example the shape and form of a chair. I’m passionate about encouraging young people to become more interested in science and engineering.

Yun Yee Leung’s robot, ‘holding’ a brush to a piece of paper, completing a black-and-white sketch of a fish.

Yun Yee Leung’s robot paints a traditional portrait. Credit: Veronica Sanchis for Nature.

Yun Yee Leung’s robot paints a traditional portrait. Credit: Veronica Sanchis for Nature.

I was born in Hong Kong and have always found it a diverse city. People come to live and work here from all over the world. The GBA project is connecting the city more firmly to the Chinese mainland. For example, my university set up a start-up incubator called InnoHub in its Shenzhen Research Institute in 2018, which is a centre for CUHK researchers and alumni to found companies in Shenzhen. Over the past 2 years, 45 start-up teams have joined, including a medical-imaging company called Imsight and a voice-recognition team called VoiceAI Tech. I think these kinds of initiative will attract more scientists and engineers to come and work in the area.

Because Hong Kong is an international financial centre, start-up projects that launch there have access to investors from across the world, whereas the manufacturing and fast prototyping can be done in factories on the Chinese mainland. The city is also well connected by trains and roads to manufacturing cities such as Guangzhou and Shenzhen.

I know many CUHK students who are planning to join or establish start-ups in the GBA after they graduate.

Yun Yee Leung is a PhD student in engineering at the Chinese University of Hong Kong.

The disease detective

Nan Zong

Nan Zong holds a backpack and looks at the camera, with a running track in the background.

Credit: Wang Lei for Nature .

Credit: Wang Lei for Nature .

I’m working on developing microfluidic technology that can diagnose diseases, such as cancer, by identifying their biomarkers in an extremely small amount — a pinprick’s worth — of blood. This is part of my master’s degree in biomedical engineering at the Southern University of Science and Technology (SUSTech) in Shenzhen. We run the blood sample over a microchip that has chemicals embedded in it. Then we use molecular diagnostic tools to identify whether a reaction occurs that indicates the presence of a disease. We also analyse physical changes to the sample.

Biomedical engineer Nan Zong inspects a sample in a lab at the Southern University of Science and Technology (SUSTech) in Shenzhen. Credit: Wang Lei for Nature.

We are still very much in the research stage, as are other teams across the world doing similar work, but we hope that our technology could be used in hospitals within five years.

I grew up in Jining in Shandong province, in the north of China, and in 2015 moved south to the city of Chongqing to do my degree in medical laboratory sciences. I really like living in Shenzhen, where I’ve been based since 2019, because I see many young people like me. They are constantly learning, competing, cooperating, breaking the old ways of doing things and starting new projects. SUSTech is a very young campus: around 40% of the professors are under 35 years old.

One of the reasons I moved here is because the GBA offers more entrepreneurial opportunities for young scientists than I’ve experienced in other cities. For example, in May this year, Shenzhen established the country’s first national innovation centre for medical devices.

This kind of initiative gives students at SUSTech the chance to collaborate with Chinese medical-equipment companies such as Mindray in Shenzhen, which is the kind of company I’d like to work for some day.

There are also other funding schemes, such as the Guangdong–Shenzhen joint fund, that offer grants to encourage advanced research, and the Shenzhen–Hong Kong Youth Innovation Entrepreneurship Base that helps to incubate start-ups.

Nan Zong in a gym at SUSTech, which provides this and other such facilities for its students and staff. Credit: Wang Lei for Nature.

After I graduate, I’m interested in continuing work on medical diagnostic tools that can be used anywhere. In the future, people might be able to check their health while in the supermarket, for instance — with a pinprick blood test. To me, this is meaningful work that’s full of challenges.

Nan Zong is doing a master’s degree in biomedical engineering at the Southern University of Science and Technology in Shenzhen.

Nan Zong holds a sample up to inspect it, in the middle of a lab.

Biomedical engineer Nan Zong inspects a sample in a lab at the Southern University of Science and Technology (SUSTech) in Shenzhen. Credit: Wang Lei for Nature.

Biomedical engineer Nan Zong inspects a sample in a lab at the Southern University of Science and Technology (SUSTech) in Shenzhen. Credit: Wang Lei for Nature.

Nan Zong sits cross-legged in a gym.

Nan Zong in a gym at SUSTech, which provides this and other such facilities for its students and staff. Credit: Wang Lei for Nature.

Nan Zong in a gym at SUSTech, which provides this and other such facilities for its students and staff. Credit: Wang Lei for Nature.

The Greater Bay Area: a potted history

The region is central to the development of China and its high-tech ambitions.

A sketch of solders with canon in the foreground, with two large mountains dotted with structures in the background.

A British sketch of soldiers transporting cannon during the first Opium War in 1840. Credit: DeAgostini/Getty Images .

A British sketch of soldiers transporting cannon during the first Opium War in 1840. Credit: DeAgostini/Getty Images .

1557:
Portugal acquires a permanent lease on Macau.

1839–42:
First Opium War ends with the Treaty of Nanking, ceding Hong Kong to Britain, opening major coastal cities to global trade and beginning what is known in China as the Century of Humiliation by foreign powers.

1887:
Macau becomes a Portuguese colony with the signing of the Treaty of Peking.

1898:
Britain obtains a 99-year lease on Hong Kong and the New Territories north of Hong Kong Island.

1912:
Sun Yat-sen deposes Qing emperor Puyi, establishing the Republic of China.

1949:
Mao Zedong establishes the People’s Republic of China.

1963:
At a conference in Shanghai, Chinese premier Zhou Enlai calls on China’s scientists and engineers to develop China’s agriculture, industry, national defence, and science and technology.

Boats move along the Pearl River in Guangzhou, 1979. Credit: Nik Wheeler/Corbis via Getty Images .

1976:
Deng Xiaoping emerges as de facto head of China and initiates major economic reform, including a vision for sustained, long-term increased investment in science and technology.

1980:
Deng Xiaoping designates Shenzhen a ‘special economic zone’: encouraging foreign investment and rapid industrialization.

1997:
Sovereignty over Hong Kong is transferred from Britain to China, and the area is granted the status of a ‘special administrative region’, with separate governing systems and a largely independent democracy.

1999:
Sovereignty over Macau is transferred from Portugal to China. Similarly to Hong Kong, the island is given the status of a special administrative region.

2015:
China announces its ‘Made in China 2025’ plan to become a supplier of high-quality, technologically advanced goods and services within ten years.

2016:
China overtakes the United States as the world’s most prolific producer of scientific papers.

Modern Zhuhai and Macau. Credit: Jingying Zhao/Getty Images.

2018:
The final stage of a high-speed rail network is opened, linking Hong Kong to Beijing via Guangzhou and Shenzhen. The vast Hong Kong–Zhuhai–Macau Bridge also opens.

2019–20:
International media attention focuses on Hong Kong because of protests against a proposed extradition law, amid growing scrutiny in China and elsewhere over the region’s continued autonomy.

Small boats move up and down a wide river, with buildings on each coastline.

Boats move along the Pearl River in Guangzhou, 1979. Credit: Nik Wheeler/Corbis via Getty Images .

Boats move along the Pearl River in Guangzhou, 1979. Credit: Nik Wheeler/Corbis via Getty Images .

A brightly lit view of city buildings, with a busy road on one side of the image.

Modern Zhuhai and Macau. Credit: Jingying Zhao/Getty Images.

Modern Zhuhai and Macau. Credit: Jingying Zhao/Getty Images.

The beauty biologist

Jili Yang

Jili Yang, surrounded by boxes and holding a pair of electronic toothbrushes, smiles at the camera.

Credit: Wang Lei for Nature.

Credit: Wang Lei for Nature.

I work at Kitty Annie, a beauty-technology company based in Shenzhen that was started in 2019. I arrived in Shenzhen in April this year, when people were able to travel again in China after coronavirus lockdowns eased.

This was a change of plan for me: I had moved home to Qingdao, a city on the east coast in Shandong province, after leaving London last September. I had intended to apply for PhD positions in England but began looking for positions closer to home because of COVID-19.

I like Kitty Annie. I enjoy being part of an entrepreneurial team. Every day is busy and full, and work takes up most of my life. We launched our first line of products this year, and we sell a body-hair removal kit and hair-removal gel. My job is to look for new ingredients to put in future products, and to continue development of our current ones. For example, I’ve recently been looking at compounds in strawberries, blueberries, blackberries and acai berries that could help to produce an anti-ageing effect when added to skin creams.

Yang sits facing the camera on a long, low stack-able chair.

Yang says he enjoys the entrepreneurial environment at the beauty-technology firm Kitty Annie in Shenzhen. Credit: Wang Lei for Nature.

Yang says he enjoys the entrepreneurial environment at the beauty-technology firm Kitty Annie in Shenzhen. Credit: Wang Lei for Nature.

Every day is busy and full, and work takes up most of my life. We launched our first line of products this year, and we sell a body-hair removal kit and hair-removal gel. My job is to look for new ingredients to put in future products, as well as continue to develop current ones. For example, I’ve recently been looking at the properties in strawberries, blueberries, blackberries and acai berries that could help produce anti-ageing effects when added to skin creams.

We try not to test our formulas on animals, where possible. This is unusual in China.

To choose which ingredients to use, I explore published research in cosmetics, data from suppliers and the results of tests we order from external laboratories to come up with new formulas.

The city feels full of opportunity.

My master’s degree in structural and molecular biology at Imperial College London gave me a deeper understanding of what to look for when reading information about ingredients sent by manufacturers. I’ll look at the experiments they performed and evaluate whether their results seem reasonable. For example, I recently chose a blueberry extract, made in the Daxing’anling region in northern China, after reviewing materials from domestic sellers and overseas.

The main advantage of Shenzhen to me is the cuisine. The city attracts immigrants from other cities, and they’ve brought their top culinary skills. My favourite dishes are chopped pepper fish heads from Hunan province, pea noodles from Chongqing and donburi, which is a Japanese rice dish.

Yang sits in front of a table of food, including a whole fillet of fish.

Jili Yang says Shenzhen is a great melting pot for different cuisines. Credit: Wang Lei for Nature.

Jili Yang says Shenzhen is a great melting pot for different cuisines. Credit: Wang Lei for Nature.

My home town of Qingdao is famous for its beautiful coastal scenery and temperate climate. In comparison, I find the weather in the southern city of Shenzhen rather hot and humid.

I hear a lot of negative opinions about living in Shenzhen: the city has grown rapidly and still has many problems and areas to be improved. Resources in areas such as education and health care are limited: people struggle to get access to good-quality social services.

But I think Shenzhen’s a great place for young people to work. The city feels full of opportunity. You can easily find work in exciting, emerging industries, such as Internet-based companies.

Jili Yang is a biologist at Kitty Annie in Shenzhen.

The engineer

Tao Yang

Tao Yang stands next to a vast turbine fan.

I help to develop new materials for advanced engineering applications, such as turbine blades and turbochargers for use in aeroplanes, as part of my work as an assistant professor at the Department of Materials Science and Engineering at the City University of Hong Kong.

For example, our team recently developed a new type of material by adding boron to a metal alloy. Adding this element causes changes in the crystalline structure of the material that make it stronger, more flexible and capable of withstanding high temperatures.

Our group is hoping to get a patent for this work and then we can look for investors to start a business with, or work with the steel and automobile companies in the GBA to develop the product.

One remarkable thing about this city, and the GBA, is its lightning-fast take-up of new technologies. Many high-tech companies have headquarters in the GBA, such as Huawei and Tencent. For early-career scientists like me, this feels like a huge opportunity to realize creative ideas and work at the cutting-edge of technology.

I think this sort of career path is becoming more common.

In 2015, I was awarded a PhD grant of US$41,000 by the regional government that enabled me to move to Hong Kong and join this university. The university’s Hong Kong Institute for Advanced Study then awarded me a postdoc fellowship of $5,100 per month, which ended in August. I stayed at the university as an assistant professor.

I think this sort of career path is becoming more common: when I graduated from Xiamen University in 2014 with my bachelor’s degree, few students on my course planned to come to the GBA to work or continue their research. But now, more of my peers tell me they’re going to southern cities to work as engineers. I also get the impression that more students are thinking of pursuing their PhD and postdoc studies in cities such as Hong Kong and Shenzhen, rather than Beijing and Shanghai.

A harbour, surrounded by skyscrapers, is shaded orange by the sunrise.

Sunrise over Victoria Harbour in Hong Kong. Credit: Ratnakorn Piyasirisorost/Moment/Getty Images.

Sunrise over Victoria Harbour in Hong Kong. Credit: Ratnakorn Piyasirisorost/Moment/Getty Images.

During the coronavirus pandemic, Hong Kong was not subject to lockdown in the same way as the Chinese mainland, so I was still able to go into work wearing a mask. The main obstacle was recruiting new researchers, because many students from the Chinese mainland were reluctant to travel to Hong Kong or overseas, because they didn’t want to have to go through quarantine.

Cities such as Shenzhen and Dongguan in the GBA have become international hubs of advanced manufacturing where graduates in my field can find good jobs to start their careers. These cities also generally provide higher salaries to young people than cities such as Xiamen. I think this is because they’re growing so rapidly.

Tao Yang is a materials scientist at the City University of Hong Kong.


Interviews by Sarah O’Meara and additional research by Ivy Huang. These interviews have been edited for length and clarity.

This article is part of the Nature Spotlight on China’s Greater Bay Area, an editorially independent supplement. Advertisers have no influence over the content.



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