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Expanded ENCODE delivers invaluable genomic encyclopedia

The third phase of the Encyclopedia of DNA Elements (ENCODE) project has generated the most comprehensive catalogue yet of the functional elements that regulate our genes.
  1. Chung-Chau Hon

    1. Chung-Chau Hon is at the RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.

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  2. Piero Carninci

    1. Piero Carninci is at the RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, Japan.

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Less than 2% of the human genome encodes proteins1. A grand challenge for genomic sciences has been mapping the functional elements — the regions that determine the extent to which genes are expressed — in the remaining 98% of our DNA. The Encyclopedia of DNA Elements (ENCODE) project, among other large collaborative efforts2–4, was established in 2003 to create a catalogue of these functional elements and to outline their roles in regulating gene expression. In nine papers in Nature5–13, the ENCODE consortium delivers the third phase of its valuable project.

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Nature 583, 685-686 (2020)

doi: https://doi.org/10.1038/d41586-020-02139-1

References

  1. International Human Genome Sequencing Consortium. Nature 431, 931–945 (2004).

    Article  PubMed  Google Scholar 

  2. Roadmap Epigenomics Consortium et al. Nature 518, 317–330 (2015).

    Article  PubMed  Google Scholar 

  3. Stunnenberg, H. G., International Human Epigenome Consortium & Hirst, M. Cell 167, 1145–1149 (2016).

    Article  PubMed  Google Scholar 

  4. The FANTOM Consortium and the RIKEN PMI and CLST (DGT). Nature 507, 462–470 (2014).

    Article  PubMed  Google Scholar 

  5. The ENCODE Project Consortium et al. Nature 583, 699–710 (2020).

    Article  Google Scholar 

  6. Meuleman, W. et al. Nature https://doi.org/10.1038/s41586-020-2559-3 (2020).

    Article  Google Scholar 

  7. Vierstra, J. et al. Nature 583, 729–736 (2020).

    Article  Google Scholar 

  8. Partridge, E. C. et al. Nature 583, 720–728 (2020).

    Article  Google Scholar 

  9. Grubert, F. et al. Nature 583, 737–743 (2020).

    Article  Google Scholar 

  10. He, Y. et al. Nature 583, 752–759 (2020).

    Article  Google Scholar 

  11. Gorkin, D. U. et al. Nature 583, 744–751 (2020).

    Article  Google Scholar 

  12. He, P. et al. Nature 583, 760–767 (2020).

    Article  Google Scholar 

  13. Van Nostrand, E. L. et al. Nature 583, 711–719 (2020).

    Article  Google Scholar 

  14. The ENCODE Project Consortium. Nature 447, 799–816 (2007).

    Article  PubMed  Google Scholar 

  15. ENCODE Project Consortium. Nature 489, 57–74 (2012).

    Article  PubMed  Google Scholar 

  16. Yue, F. et al. Nature 515, 355–364 (2014).

    Article  PubMed  Google Scholar 

  17. The ENCODE Project Consortium et al. Nature 583, 693–698 (2020).

    Article  Google Scholar 

  18. Yip, K. Y. et al. Genome Biol. 13, R48 (2012).

    Article  PubMed  Google Scholar 

  19. Regev, A. et al. eLife 6, 27041 (2017).

    Article  Google Scholar 

  20. Dekker, J. et al. Nature 549, 219–226 (2017).

    Article  PubMed  Google Scholar 

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