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My first paper rejection came as a bit of a shock. By the time it came to submission, I was feeling fairly confident because my supervisors and collaborators were happy. We couldn’t all be wrong about our paper — could we? Eight years on, I still remember opening that rejection e-mail alone in my office in Zurich, Switzerland. I felt as if I had failed. But one of the hardest lessons I’ve had to learn is that a paper rejection is just a setback, not a failure. You can still submit your paper elsewhere, or keep working on it.