A mutational signature that can be made by a bacterium arises in human colon cancer

Yang, Ye; Jobin, Christian

doi:10.1038/d41586-020-00818-7

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23 March 2020

A mutational signature that can be made by a bacterium arises in human colon cancer

Studies have pointed to a link between colon cancer and a gut bacterium that produces DNA-damaging molecules. The discovery of a mutational signature linked to these bacteria in human colon cancer supports this association.

Ye Yang⁰ &
Christian Jobin¹

Ye Yang
1. Ye Yang is in the Department of Medicine, University of Florida, Gainesville, Florida 32611, USA.
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Christian Jobin
1. Christian Jobin is in the Department of Medicine, University of Florida, Gainesville, Florida 32611, USA, and in the Department of Infectious Diseases and Pathology, and the Department of Anatomy and Cell Biology, University of Florida.
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Understanding what causes colorectal cancer (CRC) could help to combat this disease of the colon. Writing in Nature, Pleguezuelos-Manzano et al.¹ report evidence that strengthens a previously suspected connection to a type of gut bacterium. The authors implicate this microbe by pinpointing bacterial ‘fingerprints’ in DNA alterations found in CRC cells.

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Nature 580, 194-195 (2020)

doi: https://doi.org/10.1038/d41586-020-00818-7

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