NATURE BRIEFING

Daily briefing: Why cigarette smoking increases the risk of diabetes

In mice, nicotine seems to mess with the signalling pathway that links the brain to the pancreas. Plus: a second scientist has moved closer to creating gene-edited babies and we remember the first person to walk in space.

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Today we hear that a second scientist has moved closer to creating gene-edited babies, discover how smoking might trigger diabetes and remember the first person to walk in space.

Denis Rebrikov, Russian biochemist.

Denis Rebrikov plans to soon publish his experiments to repair genes in human eggs.Credit: Andrey Rudakov/Bloomberg/Getty

Russian ‘CRISPR-baby’ scientist has started work

Biologist Denis Rebrikov says he has started gene editing human eggs as a step on the path towards becoming the second scientist to make genome-edited babies. Rebrikov announced earlier this year that he wants to follow in the controversial footsteps of He Jiankui, who edited a gene linked to HIV resistance. Rebrikov has said that he is working with five deaf couples and hopes to eventually edit a gene linked to deafness, called GJB2, in their babies (although the eggs he’s practising on now were donated by hearing women).Rebrikov responds bluntly to those who argue that clinical research with edited embryos should slow down until international frameworks are in place. “Are you serious?” he told Nature in an email. “Where did you see the researcher willing to slow down?”

Nature | 7 min read

Ambitious project to map Canada’s geology

Earth scientists are taking the first steps towards a hugely ambitious effort to establish a network of geophysical observatories across the Great White North. The Earth-system Observing Network-Réseau d’Observation du Système Terrestre (EON-ROSE) project would study everything from the inner Earth to the upper atmosphere. Researchers hope to drum up some of the roughly Can$100 million (US$75 million) needed by partnering with companies that want to prospect for geothermal energy sources, minerals and precious metals.

Nature | 4 min read

Smoking’s effect on the brain might trigger diabetes

The stimulation that makes nicotine so addictive might also be why it raises the risk of diabetes — and why people with diabetes might find it harder to quit. In mice, nicotine seems to mess with the signalling pathway that links the brain to the pancreas, triggering an increase in blood sugar levels. Repeated over time, that can wear out the insulin-signalling pathways in cells and eventually lead to diabetes. “Ultimately, a disease like diabetes may be originating in the brain or may reflect dysregulated brain-body interactions, and I think that’s absolutely fascinating and absolutely terrifying,” says neuroscientist Paul Kenny.

Chemical & Engineering News | 4 min read

Go deeper with expert analysis in the Nature News & Views article.

Reference: Nature paper

FEATURES & OPINION

Data on child deaths are a call for justice

As a paediatrician treating the children of political prisoners during the dictatorship of Augusto Pinochet in Chile, Michelle Bachelet experienced at first hand how good health relies on much more than access to a doctor. Later, as president of Chile, Bachelet applied that knowledge to help ensure that death rates for children under five dropped significantly. Now the UN high commissioner for human rights, Bachelet analyses how we should respond to a new study that shows widespread improvements in child health, tempered by vast inequalities even within the same country.

Nature | 4 min read

Reference: Nature paper

An artist and a spacewalker

Cosmonaut Alexei Leonov, the first person to walk in space, also created the first artwork in space — he had brought coloured pencils on his 1965 Voskhod mission and captured a sketch of the brightly coloured sliver of Earth’s atmosphere. Leonov came close to death on the mission: he struggled to initially fit back through the airlock, and a guidance-system failure on re-entry meant the crew spent two days marooned in a snowy forest before being rescued. But it was the beauty and wonder of his few minutes floating free in the dark that stayed with him, and he returned to the subject in his paintings for the rest of his life. Leonov died on 11 October at the age of 85.

The Economist | 4 min read

Podcast: Mapping childhood mortality

On this week’s Nature Podcast: what mapping childhood mortality at a regional level has revealed, and an insight into the ‘de novo’ genes that arise from non-coding DNA.

Nature Podcast | 24 min listen

Subscribe to the Nature Podcast on iTunes, Google Podcasts or Spotify.

BOOKS & ARTS

When capitalisms collide

In the present tumult, the prevailing mode of economic organization is unsustainable. That’s the common conclusion of three new books with very different perspectives on prosperity, justice and environmental health. Public-policy researcher Diane Coyle compares the efforts from, among others, ur-capitalist and philanthropist George Soros and Nobel laureate Joseph Stiglitz.

Nature | 7 min read

In the shadow of artificial light

Incremental improvements in artificial lighting, from whale oil to the incandescent light bulb, were no straightforward march of progress, reveal two new books. Historian David Nye reviews what they have to say about the complex history of lighting technologies.

Nature | 5 min read

Science books: new in paperback

Mary Craig’s pick of the best of this season’s releases includes social-media war, reclaiming classics from the alt-right, and a fusion of physics and dance.

Nature | 4 min read

As we remember the life of the late cosmonaut Alexei Leonov, here’s another space-walking first: as I write this, NASA astronauts Christina Koch and Jessica Meir are outside the International Space Station — the first all-female crew to venture into the vacuum. Don’t leave me out in the cold: please send your feedback on this newsletter to briefing@nature.com.

Flora Graham, senior editor, Nature Briefing

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