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Super-precise new CRISPR tool could tackle a plethora of genetic diseases

The system allows researchers more control over DNA changes, potentially opening up conditions that have challenged gene-editors.
  1. Heidi Ledford
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For all the ease with which the wildly popular CRISPR–Cas9 gene-editing tool alters genomes, it’s still somewhat clunky and prone to errors and unintended effects. Now, a recently developed alternative offers greater control over genome edits — an advance that could be particularly important for developing gene therapies.

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Nature 574, 464-465 (2019)

doi: https://doi.org/10.1038/d41586-019-03164-5

References

  1. Anzalone, A. V. et al. Nature https://doi.org/10.1038/s41586-019-1711-4 (2019).

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  2. Komor, A. C. et al. Nature 533, 420-424 (2016).

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