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William Kaelin, Peter Ratcliffe and Gregg Semenza have together worked out how genes respond when oxygen is depleted.Credit: Ill. Niklas Elmedhed/Nobel Media
Medicine Nobel for discovery of how cells sense oxygen
Three researchers have won the Nobel Prize in Physiology or Medicine for describing how cells sense and respond to oxygen by switching genes on and off. Cancer researcher William Kaelin, physician-scientist Peter Ratcliffe and geneticist Gregg Semenza also won the Albert Lasker Basic Medical Research Award in 2016. Among the applications of their discovery is a better understanding of how the body reacts when oxygen levels drop owing to exercise or stroke, and efforts to manipulate the response to slow the growth of oxygen-hungry cancer tumours.
Gigantic Nile dam stirs border tensions
Ethiopia is constructing a gigantic dam on the River Nile that its government says will dramatically boost access to electricity for its citizens. But Egypt, which sits farther downstream, is concerned that filling the dam’s reservoir over five years will cause water shortages for its farmers. Egypt wants the filling to occur over seven years. Although neither side has been willing to budge so far, the countries are likely to find a compromise, says Ismail Serageldin, a former vice-president of the World Bank. “They will negotiate and meet somewhere in the middle.”
Lab-made soup yields RNA bases
Organic chemists have created in the lab the nucleobases, adenine, uracil, cytosine and guanine — known as A, U, C and G — that could have served as the building blocks of RNA on an early Earth. The team put basic molecules through a series of conditions that could have existed way back when, cycling them from wet to dry, from hot to cold, and from acidic to basic, with chemicals occasionally flowing between two ponds. The results add credence to the idea that life arose from self-replicating, RNA-based genes before organisms developed the ability to store genetic information in the molecule’s close relative, DNA.
FEATURES & OPINION
At 15, graphene is ready for prime time
Graphene, the one-atom-thick wonder material, can be described with a stack of superlatives: it’s the strongest, stiffest and most-conductive material ever measured, among other things. It even won its discoverers a Nobel prize in 2010. But, 15 years after it was discovered, how close is it to living up to its commercial promises? Nature Nanotechnology explores the graphene-based technologies on (or almost on) the market and finds that the material is on track to deliver.
Nature Nanotechnology | 12 min read
Read the whole collection: Graphene 15
“My complicity sickens me”
It’s high time that scholars learn to recognize abusive behaviour and how to tackle it, says psychologist Virginia Valian. Valian puts her own behaviour under the microscope by reconsidering her interactions with a colleague who was later found to have violated her department’s policies. And she shares how she will personally do things differently — and how we can, too.
Gender, race and field trips in South African anthropology
Archaeologist Nomawethu Hlazo speaks about her experiences as black female scientist in a mostly white male field, and her perspective on researching the origins of humanity in South Africa. “I’ve always wanted to change the world, but I thought I’d quietly do it in the lab,” she says. “But then I realized: that’s not how the world works. People need to know who you are, and they need to see you.”
Nobel by the numbers
Chemistry World has crunched the numbers and says that the average chemistry Nobel laureate is an American man in his late 50s (probably called Richard, John or Paul) who works at the University of California, Stanford or Caltech. His prizewinning work was published 16 or 17 years ago, in Nature or the Journal of the American Chemical Society, and has been cited 529 times so far. Of course, there is a lot more diversity in the individual winners, and a series of illuminating infographics tells some interesting tales.
