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Moderation of neural excitation promotes longevity

Signals emanating from the nervous system are potent modulators of longevity. It now seems that overall neural excitation is also a key determinant of lifespan.
  1. Nektarios Tavernarakis

    1. Nektarios Tavernarakis is at the Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, and the School of Medicine, University of Crete, Heraklion 71110, Crete, Greece.

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The question of why and how we age — and why only a minority of humans live to become centenarians — has fascinated people for millennia. Over the past few decades, we have learnt that the rate of ageing is highly sensitive to intrinsic and extrinsic cues, and that these cues act, by means of numerous genetic pathways, to regulate the cellular and systemic processes that ultimately influence ageing1.

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Nature 574, 338-340 (2019)

doi: https://doi.org/10.1038/d41586-019-02958-x

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