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  • OUTLOOK

Cannabis’s chemical synergies

The notion of an ‘entourage effect’ that magnifies the drug’s effects is intriguing but lacks solid evidence.
  1. Tammy Worth

    1. Tammy Worth is a freelance health-care reporter in Kansas City, Missouri.

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Jenny Wiley was a consultant for the World Health Organization in 2018 when it conducted a major review of cannabis1. The committee considered input from various groups of people, including some that were touting the importance of the entourage effect — a purported synergy between the cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD), as well as other molecules found in the plant, known as terpenoids.

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Nature 572, S12-S13 (2019)

doi: https://doi.org/10.1038/d41586-019-02528-1

This article is part of Nature Outlook: Cannabis, an editorially independent supplement produced with the financial support of third parties. About this content.

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