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Yeast cells handle stress by reprogramming their metabolism

Stressed yeast cells take up the amino acid lysine and reprogram their metabolism to free up supplies of a stress-relieving molecule. Lysine uptake therefore increases the tolerance of yeast cells to stress.
  1. Jens Nielsen

    1. Jens Nielsen is at the BioInnovation Institute, DK2200 Copenhagen N, Denmark; the Department of Biology and Biological Engineering, Chalmers University of Technology, Gothenburg, Sweden; and the Novo Nordisk Foundation Center for Biosustainability, Technical University of Denmark, Kongens Lyngby, Denmark.

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Metabolism is crucial for all living cells: it provides energy as well as the molecular building blocks required for growth. Some metabolic pathways protect cells against different types of stress, including the oxidative stress caused by other metabolic processes in the cell or by external factors. Writing in Nature, Olin-Sandoval et al.1 describe how yeast cells (Saccharomyces cerevisiae) can reprogram their metabolism so that they are better equipped to handle the oxidative stress that is caused by the accumulation of chemically reactive molecules known as reactive oxygen species (ROS).

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Nature 572, 184-185 (2019)

doi: https://doi.org/10.1038/d41586-019-02288-y

References

  1. Olin-Sandoval, V. et al. Nature 572, 249–253 (2019).

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