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  • RESEARCH HIGHLIGHT

‘Microscope’ made of DNA reveals a cell’s hidden structures

DNA tags can be used to assemble a diagram of the genetic material inside a cell.
Inferred large-scale DNA microscopy image

Individual RNA molecules (coloured dots) in a cell culture. An algorithm picked out the molecules by analysing the products of a chemical reaction and identifying their relative position. Credit: Joshua Weinstein/Broad Institute

An imaging technique that uses chemical reactions instead of light can reveal the spatial organization and sequences of DNA molecules inside cells.

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Nature 570, 419 (2019)

doi: https://doi.org/10.1038/d41586-019-01940-x

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