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Protein assembles into Archimedean geometry

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Nature 569, 340-342 (2019)


Updates & Corrections

  • Correction 13 May 2019: An earlier version of this article said that only 5 of the 11 thiol groups of an undecameric protein participate in metal-mediated connections to assemble into a pentagonal icositetrahedron. The correct number is 10 of the 11. The main text, figure and caption have been corrected accordingly.


  1. Yeates, T. O. Annu. Rev. Biophys. 46, 23–42 (2017)

    PubMed  Article  Google Scholar 

  2. Aumiller, W. M., Uchida, M. & Douglas, T. Chem. Soc. Rev. 47, 3433–3469 (2018).

    PubMed  Article  Google Scholar 

  3. Malay, A. D. et al. Nature 569, 439–443 (2019).

    Article  Google Scholar 

  4. Holden, A. Shapes, Space, and Symmetry (Columbia Univ. Press, 1971).

    Google Scholar 

  5. Padilla, J. E., Colovos, C. & Yeates, T. O. Proc. Natl Acad. Sci. USA 98, 2217–2221 (2001).

    PubMed  Article  Google Scholar 

  6. King, N. P. et al. Science 336, 1171–1174 (2012).

    PubMed  Article  Google Scholar 

  7. Lai, Y.-T. et al. Nature Chem. 6, 1065–1071 (2014).

    Article  Google Scholar 

  8. Sciore, A. et al. Proc. Natl Acad. Sci. USA 113, 8681–8686 (2016).

    PubMed  Article  Google Scholar 

  9. Bale, J. B. et al. Science 353, 389–394 (2016).

    PubMed  Article  Google Scholar 

  10. Basta, T. et al. Proc. Natl Acad. Sci. USA 111, 670–674 (2014).

    PubMed  Article  Google Scholar 

  11. Salgado, E. N., Radford, R. J. & Tezcan, F. A. Acc. Chem. Res. 43, 661–672 (2010).

    PubMed  Article  Google Scholar 

  12. Caspar, D. L. & Klug, A. Cold Spring Harb. Symp. Quant. Biol. 27, 1–24 (1962).

    PubMed  Article  Google Scholar 

  13. Sasaki, E. et al. Nature Commun. 8, 14663 (2017).

    PubMed  Article  Google Scholar 

Download references


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