For transgender people, transitioning to a life reflecting one's gender identity can be a defining process. But until recently, relatively little research had been carried out on the great social and physical changes that many go through during hormone treatment. The city of Ghent in Belgium has become a hub for trans and non binary people as they transition. Here, in 2010, a unique study of transgender people was launched: the European Network for the Investigation of Gender Incongruence (ENIGI). The study is giving researchers a comprehensive look at how hormone treatment affects different people so that they can offer more support as trans people travel through this challenging stage of life.