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Coloured scanning electron micrograph of a chimeric antigen receptor T-cell

An anti-cancer CAR T-cell. Such cells have now been engineered to fight a type of immune cancer without causing severe side effects. Credit: Eye of Science/SPL

Cancer

A cancer therapy’s grave dangers subside after a little fine-tuning

Modifying a T-cell receptor eliminates the serious side effects of an immunotherapy.

After a bioengineered upgrade, cancer-fighting immune cells no longer cause severe side effects, but are still effective against an aggressive form of cancer.

B-cell lymphoma is a malignancy of the human immune system. Some cases are treated with non-cancerous immune cells that have been isolated from the patient and genetically modified. But these CAR T cells — shorthand for chimeric antigen receptor T cells — can cause serious side effects, including multi-organ failure.

Si-Yi Chen at the University of Southern California in Los Angeles and Jun Zhu at Peking University Cancer Hospital and Institute in Beijing and their colleagues tinkered with a portion of a receptor on the T cells. They used the cells they modified to treat people with B-cell lymphoma whose cancer either had not responded to treatment or had recurred.

The 25 study participants received a range of T-cell dosages, but none of the participants reported serious side effects. In a subset of 11 participants who received a particular dose of modified T cells, 6 went into complete remission.

More Research Highlights...

Light micrograph of a human egg cell during fertilisation

As a human egg cell is fertilized, two chromosome-containing cellular structures (dotted circles, centre) merge into one — a process that often goes wrong. Credit: Pascal Goetgheluck/Science Photo Library

Developmental biology

The error-prone step at the heart of making an embryo

High-resolution imaging shows why the union between two sets of chromosomes goes awry as least as often as not.
Satellite image of broken iceberg B-44.

Dark water borders chunks of iceberg broken off a West Antarctica glacier. The melting of the region’s ice sheet could allow the bedrock to rise, sloughing water into the ocean. Credit: NASA

Climate change

Antarctic rocks on the rebound could raise sea level much more than expected

When the ice covering the west of the continent disappears, the bedrock could rise up and shove extra water into the ocean.
Monteverde Cloud Forest Preserve, Costa Rica

Mist wafts through the trees at the Monteverde Cloud Forest Biological Preserve in Costa Rica. Cloud forests around the world are threatened by development, wood collection and climate change. Credit: Stefano Paterna/Alamy

Conservation biology

Forests that float in the clouds are drifting away

Tropical cloud forests are safe havens for a vast range of creatures and plants, but they are under siege around the globe.
Illustration of a brown dwarf

A rapidly spinning brown dwarf (pictured, artist’s impression) tends to have narrow atmospheric bands; the faster the spin, the thinner the bands. Credit: NASA/JPL-Caltech

Astronomy and astrophysics

Dim stars that have failed at fusion are masters of spin

Three brown dwarfs whirl on their axes at a dizzying rate that might be close to the celestial speed limit for these bodies.
Aerial photograph of beef cattle standing at the Texana Feeders feedlot in Floresville, Texas

Large-scale facilities such as this feedlot in Floresville, Texas, help to meet the global appetite for beef and other red meat, which remains strong despite the growing consumption of chicken and fish. Credit: Daniel Acker/Bloomberg/Getty

Agriculture

Meat lovers worldwide pay climate little heed

People are eating more poultry and fish — but they’re not giving up their hamburgers.
Midshipmen at dining table eat in formation, CIRCA 1900

Midshipmen in the United States in around 1900. A study found that body-mass index, a gauge of obesity, has increased with the generations during the twentieth century. Credit: Buyenlarge/Getty

Metabolism

A century of US data documents obesity’s racially skewed rise

An analysis also finds that obesity is common at a much younger age among people born in the early 1980s than those born in the late 1950s.
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