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A mouse model for the most common form of heart failure

A mouse model that replicates the clinical features of the most common form of heart failure opens a window on the mechanisms underlying this disease, and could help scientists to explore future therapies.
  1. Dulguun Amgalan

    1. Dulguun Amgalan is in the Departments of Medicine (Cardiology) and Cell Biology, and in the Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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  2. Richard N. Kitsis

    1. Richard N. Kitsis is in the Departments of Medicine (Cardiology) and Cell Biology, and in the Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

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Heart failure is a lethal condition that affects at least 26 million people worldwide1. A preclinical model that faithfully recapitulates the most common form of this syndrome, known as heart failure with preserved ejection fraction (HFpEF), has been lacking. Writing in Nature, Schiattarella et al.2 report the development of a mouse model of HFpEF, and its use to identify a molecular pathway not previously known to have a role in this disease.

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Nature 568, 324-325 (2019)

doi: https://doi.org/10.1038/d41586-019-00983-4

References

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