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Biological sex shapes tumour evolution across cancer types

Whether a person is genetically male or female can influence the kinds of cancer-causing mutations they have.
  1. Heidi Ledford
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A person’s sex can affect the kinds of cancer-causing mutations they develop, according to a genomic analysis spanning nearly 2,000 tumours and 28 types of cancer.

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doi: https://doi.org/10.1038/d41586-019-00562-7

References

  1. Li, C. H. et al. Preprint at bioRxiv https://doi.org/10.1101/528968 (2019).

  2. Sun, T., Plutynski, A., Ward, S. & Rubin, J. B. Cell. Mol. Life Sci. 72, 3323–3342 (2015).

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  3. Gupta, S., Artomov, M., Goggins, W, Daly, M. & Tsao, H. J. Natl Cancer Inst. 107, djv221 (2015).

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  4. Natri, H. M., Sayres, M. W. & Buetow, K. Preprint at bioRxiv https://doi.org/10.1101/507939 (2018).

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