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Statistical pitfalls of personalized medicine

Illustration by David Parkins

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Nature 563, 619-621 (2018)



  1. Schork, N. J. Nature 520, 609–611 (2015).

    Article  PubMed  Google Scholar 

  2. Marquat, J., Chen, E. Y. & Prasad, V. JAMA Oncol. 4, 1093–1098 (2018).

    Article  PubMed  Google Scholar 

  3. Labenz, J. et al. Aliment. Pharmacol. Ther. 21, 739–746 (2005).

    Article  PubMed  Google Scholar 

  4. Gralnek, I. M., Dulai, G. S., Fennerty, M. B. & Spiegel, B. M. Clin. Gastroenterol. Hepatol. 4, 1452–1458 (2006).

    Article  PubMed  Google Scholar 

  5. Fedorov, V., Mannino, F. & Zhang, R. Pharm. Stat. 8, 50–61 (2009).

    Article  PubMed  Google Scholar 

  6. Senn, S. Stat. Biopharm. Res. 5, 204–210 (2013).

    Article  Google Scholar 

  7. Senn, S. Br. Med. J. 329, 966–968 (2004).

    Article  Google Scholar 

  8. Laupacis, A., Sackett, D. L. & Roberts, R. S. N. Engl. J. Med. 318, 1728–1733 (1988).

    Article  Google Scholar 

  9. Portenoy, R. K., Burton, A. W., Gabrail, N., Taylor, D. & Fentanyl Pectin Nasal Spray 043 Study Group. Pain 151, 617–624 (2010).

    Article  Google Scholar 

  10. Wegman, A. C. et al. Fam. Pract. 22, 152–159 (2005).

    Article  PubMed  Google Scholar 

  11. Araujo, A., Julious, S. & Senn, S. PLoS ONE 11, e0167167 (2016).

    Article  PubMed  Google Scholar 

  12. Senn, S. Stat. Med. 35, 966–977 (2016).

    Article  PubMed  Google Scholar 

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