Antibodies pose a double threat to HIV

Haigwood, Nancy L.

doi:10.1038/d41586-018-06773-8

NEWS AND VIEWS
26 September 2018

Antibodies pose a double threat to HIV

Drug treatments for HIV infection require the long-term use of daily medication that can have toxic side effects. A pair of HIV-targeting antibodies might offer an alternative therapeutic approach.

Nancy L. Haigwood⁰

Nancy L. Haigwood
1. Nancy L. Haigwood is in the Division of Pathobiology & Immunology, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon 97006, USA.
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It is estimated that 36.9 million people worldwide are infected with HIV (go.nature.com/2pugvhd). Drug treatment can prevent this infection from developing into AIDS and becoming lethal, by controlling the level of virus in the bloodstream. However, this therapy doesn’t eradicate HIV, and is associated with toxicity and conditions such as metabolic disorders¹. As part of ongoing efforts to improve the treatment options available, clinical-trial results are now reported in two papers from the same research group — one in Nature by Mendoza et al.² and the other by Bar-On et al.³ in Nature Medicine. The studies assess the effects of a treatment for HIV that uses two antibodies to target a viral protein.

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Nature 561, 468-470 (2018)

doi: https://doi.org/10.1038/d41586-018-06773-8

References

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[1] Paula, A. A., Falcão, M. C. N. & Pacheco, A. G. AIDS Res. Ther. 10, 32 (2013).
Article PubMed Google Scholar

[2] Mendoza, P. et al. Nature 561, 479–484 (2018).
Article Google Scholar

[3] Bar-On, Y. et al. Nature Med. https://doi.org/10.1038/s41591-018-0186-4 (2018).
Article Google Scholar

[4] Sengupta, S. & Siliciano R. F. Immunity 48, 872–895 (2018).
Article PubMed Google Scholar

[5] Boritz, E. A. et al. Cell 166, 1004–1015 (2016).
Article PubMed Google Scholar

[6] Pegu, A., Hessell, A. J., Mascola, J. R. & Haigwood, N. L. Immunol. Rev. 275, 296–312 (2017).
Article PubMed Google Scholar

[7] Caskey, M. et al. Nature 522, 487–491 (2015).
Article PubMed Google Scholar

[8] Bar, K. J. et al. N. Engl. J. Med. 375, 2037–2050 (2016).
Article PubMed Google Scholar

[9] Scheid, J. F. et al. Nature 535, 556–560 (2016).
Article PubMed Google Scholar

[10] Ledgerwood, J. E. et al. Clin. Exp. Immunol. 182, 289–301 (2015).
Article PubMed Google Scholar

[11] Mayer, K. H. et al. PLoS Med. 14, e1002435 (2017).
Article PubMed Google Scholar

[12] Scheid, J. F. et al. Science 333, 1633–1637 (2011).
Article PubMed Google Scholar

[13] Zhou, T. et al. Science 329, 811–817 (2010).
Article PubMed Google Scholar

[14] Rothenberger, M. K. et al. Proc. Natl Acad. Sci. USA 112, E1126–E1134 (2015).
Article PubMed Google Scholar

[15] Kearney, M. F. et al. PLoS Pathog. 10, e1004010 (2014).
Article PubMed Google Scholar

[16] Hessell, A. J. et al. Nature Med. 22, 362–368 (2016).
Article PubMed Google Scholar

[17] Liu, J. et al. Science 353, 1045–1049 (2016).
Article PubMed Google Scholar

[18] Shingai, M. et al. Nature 503, 277–280 (2013).
Article PubMed Google Scholar

[19] Barouch, D. H. et al. Nature 503, 224–228 (2013).
Article PubMed Google Scholar

[20] Nishimura, Y. et al. Nature 543, 559–563 (2017).
Article PubMed Google Scholar

Antibodies pose a double threat to HIV

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