Put to sleep by immune cells

Liblau, Roland S.

doi:10.1038/d41586-018-06666-w

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19 September 2018

Put to sleep by immune cells

The sleep disorder narcolepsy is linked to immune-system genes and is caused by the loss of neurons that express the protein hypocretin. Hypocretin-targeting immune cells have now been found in people with narcolepsy.

Roland S. Liblau⁰

Roland S. Liblau
1. Roland S. Liblau is at the Center for Physiopathology of Toulouse Purpan, University of Toulouse, CNRS, INSERM, Toulouse III University, Toulouse 31024, France.
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The events that lead to the sleep disorder narcolepsy are a long-standing mystery. Writing in Nature, Latorre et al.¹ reveal that people with narcolepsy have unusually high levels of a type of immune cell called a T cell, which targets proteins normally present in neurons in the brain. This finding raises the question of whether narcolepsy arises because T cells unleash an autoimmune response against neurons that are important for sleep regulation.

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Nature 562, 46-48 (2018)

doi: https://doi.org/10.1038/d41586-018-06666-w

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