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Experimental Ebola drugs face tough test in war zone

Researchers are devising a clinical-trial protocol to test three medicines in Africa’s latest outbreak.
  1. Amy Maxmen
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Health workers fighting the ongoing Ebola outbreak in the Democratic Republic of the Congo (DRC) have given nearly 20 people experimental drugs to treat the virus since mid-August. But because the drugs have been dispensed on a case-by-case, ‘compassionate use’ basis, it is hard to know whether any are effective. Now, desperate to determine which therapy works best, researchers from the DRC and US governments, the World Health Organization and other groups are meeting this week to plan a clinical trial that will compare multiple drugs as the outbreak continues.

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Nature 561, 14 (2018)

doi: https://doi.org/10.1038/d41586-018-06132-7

References

  1. The PREVAIL II Writing Group. N. Engl. J. Med. 375, 1448-1456 (2016).

    Article  PubMed  Google Scholar 

  2. Davey, R. T. et al. J. Infect. Dis. https://doi.org/10.1093/infdis/jiy334 (2018).

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