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Rethinking WNT signalling

The identification of genetic mutations that can hinder the development of human limbs has led to the discovery of an unanticipated mode of regulation for the WNT signalling pathway during limb development.
  1. Jessica A. Lehoczky

    1. Jessica A. Lehoczky is in the Department of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.

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  2. Clifford J. Tabin

    1. Clifford J. Tabin is in the Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.

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After more than 30 years of intense study, the major intercellular signalling systems that orchestrate embryonic development and tissue maintenance are reasonably well understood. Although there are many crucial details yet to be worked out, there is a tendency among researchers in the field to think that the major players in these signalling pathways — and the ways in which they interact — are known. In a paper in Nature, Szenker-Ravi et al.1 remind us that this is not necessarily the case.

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Nature 557, 495-496 (2018)

doi: https://doi.org/10.1038/d41586-018-04820-y

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