A stockpile of antiviral defences

Levesque, Sébastien; Moineau, Sylvain

doi:10.1038/d41586-018-04367-y

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16 April 2018

A stockpile of antiviral defences

The full list of weapons used by bacteria against viruses is not known. A computational approach has uncovered nine previously unidentified antiviral systems, encoded by genes near known defence genes in bacterial genomes.

Sébastien Levesque⁰ &
Sylvain Moineau¹

Sébastien Levesque
1. Sébastien Levesque is in the Department of Biochemistry, Microbiology and Bioinformatics, Faculty of Sciences and Engineering, Laval University, Quebec City, Quebec G1V 0A6, Canada.
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Sylvain Moineau
1. Sylvain Moineau is in the Department of Biochemistry, Microbiology and Bioinformatics, Faculty of Sciences and Engineering, Laval University, Quebec City, Quebec G1V 0A6, Canada, and at the Félix d’Hérelle Reference Center for Bacterial Viruses, Laval University.
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Fighting viruses is no easy task. Bacteria have survived attacks by viruses called phages by evolving sophisticated defence strategies that enable them to thrive even in virus-rich ecosystems. However, phages have evolved counter-tactics to thwart such mechanisms¹, leading to a biological arms race. Now Doron et al.² report the identification of previously unknown antiviral systems in bacteria.

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Nature 556, 318-319 (2018)

doi: https://doi.org/10.1038/d41586-018-04367-y

References

Samson, J. E., Magadán, A. H., Sabri, M. & Moineau, S. Nature Rev. Microbiol. 11, 675–687 (2013).
Article PubMed CAS Google Scholar
Doron, S. et al. Science 359, eaar4120 (2018).
Article PubMed CAS Google Scholar
Labrie, S. J., Samson, J. E. & Moineau, S. Nature Rev. Microbiol. 8, 317-327 (2010).
Article PubMed CAS Google Scholar
Snyder, L. Mol. Microbiol. 15, 415–420 (1995).
Article PubMed CAS Google Scholar
Pingoud, A., Wilson, G. G. & Wende, W. Nucleic Acids Res. 42, 7489–7527 (2014).
Article PubMed CAS Google Scholar
Barrangou, R. et al. Science 315, 1709–1712 (2007).
Article PubMed CAS Google Scholar
Jinek, M. et al. Science 337, 816–822 (2012).
Article PubMed CAS Google Scholar
Paez-Espino, D. et al. Nature 536, 425–430 (2016).
Article PubMed CAS Google Scholar
Makarova, K. S., Wolf, Y. I., Snir, S. & Koonin, E. V. J. Bacteriol. 193, 6039–6056 (2011).
Article PubMed CAS Google Scholar
Kauffman, K. M. et al. Nature 554, 118–122 (2018).
Article PubMed CAS Google Scholar
Dupuis, M.-È., Villion, M., Magadán, A. H. & Moineau, S. Nature Commun. 4, 2087 (2013).
Article PubMed CAS Google Scholar