The healthy diabetic cavefish conundrum

Rétaux, Sylvie

doi:10.1038/d41586-018-03242-0

NEWS AND VIEWS
21 March 2018

The healthy diabetic cavefish conundrum

Some Mexican cavefish have a mutation in an insulin receptor protein that affects blood-glucose regulation. The same mutation causes diabetes and health problems in humans, but the diabetic cavefish thrive.

Sylvie Rétaux⁰

Sylvie Rétaux
1. Sylvie Rétaux is at the Paris-Saclay Institute of Neuroscience, University of Paris-Sud and University of Paris-Saclay, Gif-sur-Yvette 91198, France.
View author publications

You can also search for this author in PubMed Google Scholar

Access through your institution

Buy or subscribe

Blind Mexican cavefish (Astyanax mexicanus) live in dark caves, a challenging environment that has shaped their evolution. In a paper in Nature, Riddle et al.¹ reveal the surprising way in which cavefish regulate their glucose metabolism, a finding that might have implications for our understanding of human diabetes.

Access options

Access through your institution

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Learn more

Prices may be subject to local taxes which are calculated during checkout

Nature 555, 595-597 (2018)

doi: https://doi.org/10.1038/d41586-018-03242-0

References

Riddle, M. R. et al. Nature 555, 647–651 (2018).
Article Google Scholar
Aspiras, A. C., Rohner, N., Martineau, B., Borowsky, R. L. & Tabin, C. J. Proc. Natl Acad. Sci. USA 112, 9668–9673 (2015).
Article PubMed CAS Google Scholar
Hüppop, K. Environ. Biol. Fishes 17, 229–308 (1986).
Article Google Scholar
Moran, D., Softley, R. & Warrant, E. J. PLoS ONE 9, e107877 (2014).
Article PubMed CAS Google Scholar
Atray A. et al. J. Diabetol. 4 (2), 2 (2013).
Google Scholar
Carrera, P. et al. Hum. Mol. Genet. 2, 1437–1441 (1993).
Article PubMed CAS Google Scholar
Savage, D. B. & Semple, R. K. Curr. Opin. Lipidol. 21, 329–336 (2010).
Article PubMed CAS Google Scholar
Toyoshima, Y. et al. Endocrinology 149, 5996–6005 (2008).
Article PubMed CAS Google Scholar
Yang, B.-Y. et al. Am. J. Physiol. Endocrinol. Metab. http://dx.doi.org/10.1152/ajpendo.00227.2017 (2017).
Article Google Scholar
Mitchell, R. W., Russell, W. H. & Elliott, W. R. Spec. Publ. Mus. Texas Tech. Univ. 12 (1977).
Simon, V. et al. EvoDevo 8, 23 (2017).
Article PubMed Google Scholar