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  • NEWS FEATURE

A reboot for chronic fatigue syndrome research

Research into this debilitating disease has a rocky past. Now scientists may finally be finding their footing.
  1. Amy Maxmen
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Elizabeth Allen keeps careful records of the many treatments she has undergone to relieve the symptoms of chronic fatigue syndrome. Credit: Preston Gannaway for Nature

Name a remedy, and chances are that Elizabeth Allen has tried it: acupuncture, antibiotics, antivirals, Chinese herbs, cognitive behavioural therapy and at least two dozen more. She hates dabbling in so many treatments, but does so because she longs for the healthy days of her past. The 34-year-old lawyer was a competitive swimmer at an Ivy-league university when she first fell ill with chronic fatigue syndrome, 14 years ago. Her meticulous records demonstrate that this elusive malady is much worse than ordinary exhaustion. “Last year, I went to 117 doctor appointments and I paid $18,000 in out-of-pocket expenses,” she says.

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Nature 553, 14-17 (2018)

doi: https://doi.org/10.1038/d41586-017-08965-0

References

  1. Lombardi, V. C. et al. Science 326, 585–589 (2009).

    Article  PubMed  CAS  Google Scholar 

  2. White, P. D. et al. Lancet 377, 823–836 (2011).

    Article  PubMed  CAS  Google Scholar 

  3. White, P. D., Goldsmith, K., Johnson, A. L., Chalder, T. & Sharpe, M. Psychol. Med. 43, 2227–2235 (2013).

    Article  PubMed  CAS  Google Scholar 

  4. Jason, L. A. et al. Arch. Intern. Med. 159, 2129–2137 (1999).

    Article  PubMed  CAS  Google Scholar 

  5. Institute of Medicine. Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Redefining an Illness (National Academies Press, 2015); available at http://go.nature.com/2kydjdi

  6. Nacul, L. C. et al. BMC Med. 9, 91 (2011).

    Article  PubMed  Google Scholar 

  7. Njoku, M. G. C., Jason, L. A. & Torres-Harding, S. R. J. Health Psychol. 12, 461–474 (2007).

    Article  PubMed  Google Scholar 

  8. Kapur, N. & Webb, R. Lancet 387, 1596–1597 (2016).

    Article  Google Scholar 

  9. Montoya, J. G. et al. Proc. Natl Acad. Sci. USA 114, E7150–E7158 (2017).

    Article  PubMed  CAS  Google Scholar 

  10. Fluge, Ø. et al. PLoS ONE 6, e26358 (2011).

    Article  PubMed  Google Scholar 

  11. Tuller, D. ‘Trial by error: The Troubling Case of the PACE Chronic Fatigue Syndrome Study’ Virology Blog (2015); available at http://go.nature.com/2j5fip7

  12. National Institute for Health and Care Excellence. Surveillance report 2017 — Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy): diagnosis and management (2007) NICE guideline CG53 (NICE, 2017); available at http://go.nature.com/2d4ckro

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