Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News And Views
  • Published:

Layered-up regulation in the developing brain

Modification of messenger RNAs through a process called m6A methylation facilitates dynamic temporal regulation of RNA levels in neural precursor cells, enabling fine-tuning of developing neuronal circuits in the brain.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout


  1. Herculano-Houzel, S., Manger, P. R. & Kaas, J. H. Front. Neuroanat. 8, 77 (2014).

    PubMed  PubMed Central  Google Scholar 

  2. Yoon, K. et al. Cell 171, 877–889 (2017).

    Article  CAS  Google Scholar 

  3. Li, X., Xiong, X. & Yi, C. Nature Methods 14, 23–31 (2016).

    Article  ADS  Google Scholar 

  4. Zhao, B. S., Roundtree, I. A. & He, C. Nature Rev. Mol. Cell Biol. 18, 31–42 (2017).

    Article  CAS  Google Scholar 

  5. Desrosiers, R. C., Friderici, K. H. & Rottman, F. M. Biochemistry 14, 4367–4374 (1975).

    Article  CAS  Google Scholar 

  6. Meyer, K. D. & Jaffrey, S. R. Nature Rev. Mol. Cell Biol. 15, 313–326 (2014).

    Article  CAS  Google Scholar 

  7. Patil, D. P. et al. Nature 537, 369–373 (2016).

    Article  ADS  CAS  Google Scholar 

  8. Wang, Y. et al. Nature Cell Biol. 16, 191–198 (2014).

    Article  CAS  Google Scholar 

  9. Batista, P. J. et al. Cell Stem Cell 15, 707–719 (2014).

    Article  CAS  Google Scholar 

  10. Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S. & Kriegstein, A. R. Nature 409, 714–720 (2001).

    Article  ADS  CAS  Google Scholar 

  11. Breunig, J. J., Haydar, T. F. & Rakic, P. Neuron 70, 614–625 (2011).

    Article  CAS  Google Scholar 

  12. Taverna, E., Götz, M. & Huttner, W. B. Annu. Rev. Cell Dev. Biol. 30, 465–502 (2014).

    Article  CAS  Google Scholar 

  13. Leighton, L. J. et al. Genes Brain Behav. (2017).

    Article  PubMed  PubMed Central  Google Scholar 

  14. Widagdo, J. et al. J. Neurosci. 36, 6771–6777 (2016).

    Article  CAS  Google Scholar 

  15. Sweatt, J. D. Neuron 80, 624–632 (2013).

    Article  CAS  Google Scholar 

Download references


Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Sweatt, J. Layered-up regulation in the developing brain. Nature 551, 448–449 (2017).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing