NEWS AND VIEWS

How T cells spot tumour cells

Immunotherapy can reawaken T cells to destroy tumour cells. Modelling of tumour and T-cell interactions suggests why certain tumour cells are targeted and improves predictions of immunotherapy outcome.
Siranush Sarkizova is at the Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; the Broad Institute of MIT and Harvard, Cambridge, Massachusetts; and the Department of Biomedical Informatics, Harvard Medical School, Boston.

Search for this author in:

Nir Hacohen is at the Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA, and at the Broad Institute of MIT and Harvard, Cambridge, Massachusetts.
Contact

Search for this author in:

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Nature 551, 444-446 (2017)

doi: 10.1038/d41586-017-07267-9

References

  1. 1.

    Balachandran, V. P. et al. Nature 551, 512–516 (2017).

  2. 2.

    Łuksza, M. et al. Nature 551, 517–520 (2017).

  3. 3.

    Robins, H. Curr. Opin. Immunol. 25, 646–652 (2013).

  4. 4.

    Sharma, P. & Allison, J. P. Science 348, 56–61 (2015).

  5. 5.

    Schumacher, T. N. & Hacohen, N. Curr. Opin. Immunol. 41, 98–103 (2016).

  6. 6.

    Carreno, B. M. et al. Science 348, 803–808 (2015).

  7. 7.

    Ott, P. A. et al. Nature 547, 217–221 (2017).

  8. 8.

    Sahin, U. et al. Nature 547, 222–226 (2017).

Download references

Nature Briefing

Sign up for the daily Nature Briefing email newsletter

Stay up to date with what matters in science and why, handpicked from Nature and other publications worldwide.

Sign Up