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Immunotherapy can reawaken T cells to destroy tumour cells. Modelling of tumour and T-cell interactions suggests why certain tumour cells are targeted and improves predictions of immunotherapy outcome.
Siranush Sarkizova &
Siranush Sarkizova is at the Center for Cancer Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA; the Broad Institute of MIT and Harvard, Cambridge, Massachusetts; and the Department of Biomedical Informatics, Harvard Medical School, Boston.