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When loud noises damage the inner ear, many people experience hearing loss and some complain of tinnitus, a buzzing or ringing in their ears. Karl Kandler at the University of Pittsburgh in Pennsylvania and his colleagues exposed mice to 45 minutes of loud noise. A week later, the researchers found that all exposed mice had experienced hearing loss, and about half of them failed to detect silent gaps in background noise, a sign of tinnitus in animals. In all mice with hearing loss, neuronal circuits associated with hearing were reorganized; neurons in these circuits were more likely to fire in animals with symptoms of tinnitus.