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Proteogenomics identifies anticancer targets

  1. Sarah Crunkhorn
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Targeted cancer therapies, directed at specific proteins required for tumour cell growth and survival, have proven to be an effective and precise treatment for certain types of cancer. To expand the landscape of anticancer protein targets, Savage et al. analyse Clinical Proteomic Tumor Analysis Consortium (CPTAC) proteogenomics data — including mutation, copy-number variation, DNA methylation, and transcript, protein, and phosphosite abundance data — from 1,043 treatment-naive tumour samples and 524 normal tissue samples spanning ten different cancer types, and integrate this data with other public datasets.

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Nature Reviews Drug Discovery 23, 660 (2024)

doi: https://doi.org/10.1038/d41573-024-00127-y

References

  1. Savage, S. R. et al. Pan-cancer proteogenomics expands the landscape of therapeutic targets. Cell https://doi.org/10.1016/j.cell.2024.05.039 (2024)

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