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Bispecific antibodies (bsAbs) are a diverse family of antibodies or antibody constructs that recognize two epitopes or antigens. Most bsAbs are bispecific T-cell-engagers (BiTEs), designed to redirect and/or activate CD3-expressing cytotoxic T cells (CTLs) against a specific tumour target on malignant cells. Other bsAb classes include therapies that target immune checkpoints, oncogenic signalling pathways and cytokines. Bifunctional fusion proteins are a subset of bsAbs that are typically devoid of an Fc region.