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  • RESEARCH HIGHLIGHT

Navigating a new path to Nav1.7 for pain

  1. Katie Kingwell
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Voltage-gated sodium channel Nav1.7 is expressed on sensory neurons and plays a key part in nociception. It is therefore an attractive target for pain, but efforts to directly block this channel have not resulted in successful therapies. Now, a new study reports on a small molecule that targets a Nav1.7-interacting protein, indirectly regulating Nav1.7 activity and producing analgesia in animal models of pain.

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Nature Reviews Drug Discovery 21, 18 (2022)

doi: https://doi.org/10.1038/d41573-021-00197-2

References

  1. Cai, S. et al. Selective targeting of NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in rodents. Sci. Transl Med. 13, eabh1314 (2021)

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