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Suppressing autoimmunity with mRNA vaccines

  1. M. Teresa Villanueva
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The key to treating autoimmune diseases is to generate antigen tolerance without compromising the normal immune response. This is challenging as treatments that promote tolerance to specific disease-related proteins are difficult to develop and general immunosuppressants can render patients vulnerable to other infections. Now, a team led by Ugur Sahin has designed an mRNA vaccine that can restore tolerance to myelin proteins in mice, reducing the severity of multiple sclerosis-like symptoms, while maintaining the immune response towards other antigens.

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Nature Reviews Drug Discovery 20, 99 (2021)

doi: https://doi.org/10.1038/d41573-021-00014-w

References

  1. Krienke, C. et al. A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis. Science 371, 145–153 (2021).

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