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Exosome-based candidates move into the clinic

Exosomes — small extracellular vesicles that are shed by cells — have long offered promise as drug delivery systems for small molecules, DNA, RNA and other biologic payloads. The first of these are now in the clinic.

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Nature Reviews Drug Discovery 20, 6-7 (2021)

Updates & Corrections

  • Clarification 17 December 2020: The description of the first agent from Codiak to enter clinical trials has been updated to ‘engineered exosome-based therapeutic’ to distinguish it from non-engineered exosome-based therapeutics, which are not the focus of the article.

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