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  • RESEARCH HIGHLIGHT

Strengthening the sting of immunotherapy

  1. Sarah Crunkhorn
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Cancer immunotherapies — such as immune checkpoint inhibitors — have elicited durable clinical responses, but a major subset of cancer patients do not respond. Intensive efforts are therefore focused on identifying additional immune pathways that may be modulated to enhance the efficacy of existing immunotherapies. Writing in Science, two papers now report the development of novel systemic agonists of STING (stimulator of interferon genes) that safely and effectively boost antitumour immunity in mouse cancer models.

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Nature Reviews Drug Discovery 19, 669 (2020)

doi: https://doi.org/10.1038/d41573-020-00148-3

References

  1. Chin, E. N. et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science 369, 993–999 (2020)

    PubMed  Google Scholar 

  2. Pan, B.-S. et al. An orally available non-nucleotide STING agonist with antitumor activity. Science 369, eaba6098 (2020)

    PubMed  Google Scholar 

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