IN BRIEF

Selectively targeting pathogenic TH17 cells

Search for this author in:

Targeting inflammatory TH17 cells can effectively treat autoimmune diseases, but existing approaches also inhibit homeostatic TH17 cells, thereby increasing the risk of infection. Here, Wu et al. report that inflammatory TH17 cells in the spinal cord of EAE mice express higher levels of glycolysis pathway genes than commensal bacteria-induced homeostatic TH17 cells. Specific knockout of glucose phosphate isomerase selectively eliminated inflammatory TH17 cells. Unlike homeostatic TH17 cells, inflammatory TH17 cells could not compensate by pentose phosphate pathway flux and increased mitochondrial respiration, owing to their hypoxic environment.

Nature Reviews Drug Discovery 19, 512 (2020)

References

  1. 1.

    Wu, L. et al. Niche-selective inhibition of pathogenic Th17 cells by targeting metabolic redundancy. Cell https://doi.org/10.1016/j.cell.2020.06.014 (2020)

Download references

Nature Briefing

An essential round-up of science news, opinion and analysis, delivered to your inbox every weekday.