Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • COMMENT

The RESOLUTE consortium: unlocking SLC transporters for drug discovery

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Nature Reviews Drug Discovery 19, 429-430 (2020)

doi: https://doi.org/10.1038/d41573-020-00056-6

Acknowledgements

This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777372. This Joint Undertaking receives support from the European Union’s Horizon 2020 research and innovation programme and EFPIA.

References

  1. Lin, L., Yee, S. W., Kim, R. B. & Giacomini, K. M. SLC transporters as therapeutic targets: emerging opportunities. Nat. Rev. Drug. Discov. 14, 543–560 (2015).

    PubMed  Article  Google Scholar 

  2. Luteijn, R.D. et al. SLC19A1 transports immunoreactive cyclic dinucleotides. Nature 573, 434–438 (2019).

    PubMed  Article  Google Scholar 

  3. Girardi E et al. A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs. Nat. Chem. Biol. https://doi.org/10.1038/s41589-020-0483-3 (2020).

  4. Karageorgis, G. et al. Chromopynones are pseudo natural product glucose uptake inhibitors targeting glucose transporters GLUT-1 and -3. Nat. Chem 10, 1103–1111 (2018).

    PubMed  Article  Google Scholar 

  5. Nolin, E. et al. Discovery of a ZIP7 inhibitor from a Notch pathway screen.Nat. Chem. Biol. 15, 179–188 (2019).

    PubMed  Article  Google Scholar 

Download references

Competing Interests

Although research of the RESOLUTE consortium is in the precompetitive space, the following authors are employed by companies as indicated in more detail by their affiliations: M.C., R.E., D.H., S.L., S.N., M.P., R.S., C.M.S., H.Z., S.C., A.F., M.I., G.M., L.R., F.S., L.S., M.S., P.T., S.T., H.B., A.B., E.B., Y.N.C., A.E., A.M.F., V.P., D.Z., B.H., M.L., D.S., C.V., C.W., B.B., L.C., Y.I., M.P., J.R., J.S., P.S., K.S., C.B., B.B., J.C., M.D., H.F., T.L., V.M., A.P., F.P., V.Y., P.A., C.D., F.D., V.M., A.L.S., H.S., M.W.

Nature Careers

Jobs

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing

Search

Quick links