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Opportunities and challenges with microphysiological systems: a pharma end-user perspective
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Nature Reviews Drug Discovery 20, 327-328 (2021)
doi: https://doi.org/10.1038/d41573-020-00030-2
References
Jang, K. J. et al. Reproducing human and cross-species drug toxicities using a Liver-Chip. Sci. Transl Med. 11, eaax5516 (2019).
Franzen, N. et al. Impact of organ-on-a-chip technology on pharmaceutical R&D costs. Drug Discov. Today 24, 1720–1724 (2019).
Ewart, L. et al. Navigating tissue chips from development to dissemination: a pharmaceutical industry perspective. Exp. Biol. Med. 242, 1579–1585 (2017).
Clevers, H. Modeling development and disease with organoids. Cell 165, 1586–1597 (2016).
Competing Interests
L. E. is now an employee of Emulate Inc., a company that specializes in the development and commercialization of Organ-Chips.