There is a need for more effective treatments to promote wound healing. Now, Puthia et al. have developed a novel hydrogel formulation incorporating the antimicrobial peptide TCP-25, which exhibits dual antibacterial and anti-inflammatory activity. The TCP-25 hydrogel killed Staphylococcus aureus and Pseudomonas aeruginosa in vitro and in experimental mouse models of subcutaneous infection, and also reduced LPS-induced local inflammatory responses in mice, without any signs of toxicity. In a pig wound model, the hydrogel reduced concentrations of proinflammatory cytokines and was more effective in treating and preventing S. aureus infection than the commonly used wound treatments Mepilex Ag and Prontosan.
Nature Reviews Drug Discovery 19, 92 (2020)