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  • RESEARCH HIGHLIGHT

CAR-T cells combat cardiac fibrosis

  1. Sarah Crunkhorn
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Excessive cardiac fibrosis plays an important role in the progression of various forms of cardiac disease and heart failure, but there are currently no therapies available that directly target this pathological process. Writing in Nature, Epstein and colleagues now demonstrate that engineered chimeric antigen receptor (CAR) T cells can be applied to reduce cardiac fibrosis and restore function in a mouse model of hypertensive heart failure.

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Nature Reviews Drug Discovery 18, 823 (2019)

doi: https://doi.org/10.1038/d41573-019-00162-0

References

  1. Aghajanian, H. et al. Targeting cardiac fibrosis with engineered T cells. Nature https://doi.org/10.1038/s41586-019-1546-z (2019)

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