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  • BIOBUSINESS BRIEFS

ADCK3/COQ8A: the choice target of the UbiB protein kinase-like family

  1. Christopher R. M. Asquith

    1. Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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  2. Nathan H. Murray

    1. Morgridge Institute for Research, Madison, WI, USA; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI, USA.

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  3. David J. Pagliarini

    1. Morgridge Institute for Research, Madison, WI, USA; Department of Biochemistry, University of Wisconsin–Madison, Madison, WI, USA.

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UbiB kinase-like proteins exist in archaea, bacteria and eukaryotes, and comprise ~25% of all microbial protein kinase-like (PKL) enzymes. The founding member of the UbiB family, UbiB from Escherichia coli, supports the biosynthesis of ubiquinone, also known as coenzyme Q (CoQ), by an unknown mechanism. In eukaryotes, UbiB homologues are found exclusively in mitochondria, where they likewise have been connected to CoQ biosynthesis (for a review, see Trends Biochem. Sci. 42, 824–843; 2017).

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Nature Reviews Drug Discovery 18, 815 (2019)

doi: https://doi.org/10.1038/d41573-019-00158-w

Acknowledgements

This article is part of a series from the NIH Common Fund Illuminating the Druggable Genome (IDG) programme. The goal of IDG is to catalyse research on understudied proteins from druggable gene families by providing reagents, phenotypes and a mineable database, focusing on G protein-coupled receptors, kinases and ion channels. For more information, see https://druggablegenome.net/. Work was also supported by NIH R35GM131795 (D.J.P.) and NIH T32GM008505/NSF DGE-1747503 (N.H.M.).

Competing Interests

The authors declare no competing interests.

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