Moving upstream in anticancer drug development

The development of oncology drugs traditionally begins by studying them in heavily pretreated patients, and then working ‘upstream’ to populations with earlier-stage disease. The recent FDA approval of an androgen receptor antagonist first in prostate cancer patients without demonstrable metastatic disease but at high-risk for metastasis, based on a novel metastasis-free survival end point developed by the FDA, could provide a template for a paradigm shift.
External Innovation, Johnson & Johnson, New Brunswick, NJ, USA.

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Janssen Oncology, Janssen Research and Development, Spring House, PA, USA.

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Nature Reviews Drug Discovery 18, 159-160 (2018)

doi: 10.1038/d41573-018-00006-3


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Competing Financial Interests

W.N.H. is an employee of J&J and former head of Janssen R&D. P.F.L. is an employee and stockholder of J&J/Janssen R&D.

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