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Altered neurogenesis and disrupted expression of synaptic proteins in prefrontal cortex of SHANK3-deficient non-human primate

Cell Research 27, 1293–1297 (2017) | Download Citation

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Acknowledgements

We thank Drs Weixiang Guo, Xiaoming Wang and Zhiheng Xu for discussion, Ruxiao Xing, Xudong Liu and Jinquan Gao for technical assistance, Yafeng Luo (Guangzhou Yuanxi Biotech Co., Ltd) for animal resource and care, and Samuel Hulbert for critical reading of the manuscript. The project was supported by the Ministry of Science and Technology of China (2014CB942803 and 2016YFA0501000), the Strategic Priority Research Program of the Chinese Academy of Sciences (XDB02020400), and the National Natural Science Foundation of China (31110103907, 91332206 and 31490592).

Author information

    • Hui Zhao
    •  & Zhuchi Tu

    These two authors contributed equally to this work.

Affiliations

  1. State Key Laboratory of Molecular Developmental Biology, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China

    • Hui Zhao
    • , Zhuchi Tu
    • , Huijuan Xu
    • , Yinghui Zheng
    • , Rui Tian
    • , Xiao-Jiang Li
    •  & Yong Q Zhang

  2. University of Chinese Academy of Sciences, Beijing 100101, China

    • Hui Zhao
    •  & Yong Q Zhang

  3. Guangdong-Hongkong-Macau Institute of CNS Regeneration, Ministry of Education CNS Regeneration Collaborative Joint Laboratory, Jinan University, Guangzhou, Guangdong 510632, China

    • Zhuchi Tu
    • , Sen Yan
    • , Weili Yang
    • , Xiangyu Guo
    •  & Xiao-Jiang Li

  4. The Institute for Brain Research, Collaborative Innovation Center for Brain Science, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China

    • Huanhuan Yan
    •  & Youming Lu

  5. Yuanxi Biotech Inc., Guangzhou, Guangdong 5010663, China

    • Jiezhao Zheng
    •  & Zhujun Li

  6. Department of Pediatrics and Department of Neurobiology, Duke University, Durham, NC 27710, USA

    • Yong-hui Jiang

  7. Department of Human Genetics, Emory University School of Medicine, Atlanta, GA 30322, USA

    • Xiao-Jiang Li

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Corresponding authors

Correspondence to Yong-hui Jiang or Xiao-Jiang Li or Yong Q Zhang.

Supplementary information

PDF files

  1. 1.

    Supplementary information, Figure S1

    Generation of SHANK3 gene (NCBI Reference, NW_012011200.1) mutant monkeys.

  2. 2.

    Supplementary information, Data S1

    Materials and Methods

  3. 3.

    Supplementary information, Tables S1 and S2

    The off-target analysis and mosaic analysis of mutant offspring

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DOI

https://doi.org/10.1038/cr.2017.95

(Supplementary information is linked to the online version of the paper on the Cell Research website.)