Figure 3

From: Honeysuckle-encoded atypical microRNA2911 directly targets influenza A viruses

Figure 3

MIR2911 suppressed the replication of H1N1 influenza virus but not mutant virus in mice. The mice were treated with different reagents before being inoculated with H1N1 influenza viruses (A-C) or mutant H1N1 influenza virus (D-F). The body weight was recorded every day. On days 3, 5 and 7 post infection, the mice were sacrificed, and lung tissue was obtained to measure viral replication. (A, B) Body weight changes in mice subjected to synthetic MIR2911 (A) and HS decoction (B) treatment after inoculation with 106 EID50 of H1N1 influenza virus (n = 8). (C) Viral titers (EID50) in the lungs of mice subjected to synthetic MIR2911 and HS decoction treatment at different times after inoculation with 106 EID50 of H1N1 influenza virus (n = 6). (D, E) Body weight changes in mice subjected to synthetic MIR2911 (D) and HS decoction (E) treatment after inoculation with 106 EID50 of mutant H1N1 influenza virus (n = 8). (F) Viral titers (EID50) in the lungs of mice subjected to synthetic MIR2911 and HS decoction treatment at different times after inoculation with 106 EID50 of mutant H1N1 influenza virus (n = 6). *P < 0.05; **P < 0.01. All values are the mean ± SEM. P values were determined using Student's t-test by comparing to the virus alone group.